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This is a phrase largely equivilent to fucked up or screwed up. It roughly means "in a state of disarray" and is commonly used in the phrase "to jack someone/something up". In some cases, the meaning may be slightly altered by the fact that to get "jacked" can mean to be struck or injured.
That's jacked up man. I can't belive your girlfriend is cheating on you.

I got in a wreck last night. My car got totally jacked up.
by pete August 12, 2004
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Jul 6 Word of the Day
Phrase meaning that a deceased cannot rest in peace until society changes due to the circumstances of a death.
People said rest in power for the unarmed man had been shot by the police.
by FooBarBiz October 12, 2017
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2
1. not working properly or as intended.
2. having used a large quantity of speed, cocaine, or other amphetamine.
3. cut or lacerated by means of a make-shift knife or blade. see SKIV
4. In generally poor or injured condition.
sense "1": "This is so JACKED UP! She said she'd be here at eight!"
sense "4": "I want to play, but my shoulder's still JACKED UP from last weekend.
by mainframe October 31, 2003
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3
In the military, to be given a stern talking-to by an NCO for some offense or omission.
"We all got jacked up this morning for calling him 'sergeant-major' instead of RSM."
"On course they'll jack you up if you aren't wearing dress uniform in your ID photo."
by HellHound May 06, 2015
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4
1.) To be in a state of disarray, or an undesired position.
I wrecked my truck last night, and the front-end is all jacked-up.
by Gary J. Talley March 19, 2003
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5
(Adjective )informally used to describe something that is not quite right.
Her shirt is jacked-up.
That's jacked-up, why did you do that?
This definition is jacked-up.
by Hailey Cooley August 22, 2003
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6
high on some kind of upper, coke, speed, ecstacy, etc.
this shit is fuckin great man, it had me all jacked up last night
by watzy December 28, 2006
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