An infamous nun in the Seton Keough community in Baltimore County, Maryland was actually called "Hell on Wheels"-- because of her name (Sister Helen Mercedes, which was obviously to pun) and her reputation for cruelty toward students at Seton Keough High School (which was two separate schools while "Hell on Wheels" was there).
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.