glyphomaniac Share definition Flag a crazed user of glyphosate (weed killer) in an endless crusade against invasive weeds in the garden. She's a lazy gardener. She doesn't even try to pull out the weeds. She's just a glyphomaniac. glyphomaniac by wordtree October 21, 2010 0 0 Get merch Get the glyphomaniac mug. Buy Now — $32.95 See more merch