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run like a mother fucker 

to run as fast as you can
Tony: Shit, its da cop!

Me: Run like a mother fucker!

Like a Mother Fucker 

def: a metaphor for anything that is more than average
i'm fast as a mother fucker!

you sweatin' like a mother fucker!

yo momma is loud like a mother fucker!
Like a Mother Fucker by Atkins God September 20, 2009

like a mother fucker 

like a mother fucker by Taine November 15, 2003

skeeted up like a mother fucker. 

In Sulphur Springs, to be" Skeeted up like Mother Fucker" is to high as balls on cocaine.
according to qui-qui, they was" skeeted up like a mo-fucker " that night.