Dysphoria is an experience trans, genderqueer, and non-binary people have. It describes discomfort, loathing, anxiety, and
depression revolving around one's social gender role and/or physical sex characteristics. It's a very serious experience that leads to larger anxiety/
depression problems, depersonalization, thoughts of
suicide, social withdrawal, self harm, etc.
Fallon: Where were you last
night? We missed you at the
party.
Skylar: Sorry. I had a serious bout of dysphoria and couldn't bring myself to
go.
Fallon: Oh, I understand. You didn't miss much, anyway.