To be so full of yourself that you don't allow anyone around you to run his/her game. To be such a douche that people can rightfully compare you to TJ Houshmandzadeh.
Sue doesn't really like Tyler, it's just that he takes her to the opera, gives her jewelry for every holiday, no matter how minor, and has a vacation home in Venice. It's a total doughmance.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.