Che cazzo means what the fuck in italian. The most common use is che cazzo uomo, meaning what the fuck man.
by Lobby Bobby December 17, 2016
Timmy: Hey Mario what are you doing?
Mario: mangiando (eating)
Timmy: I fucked your mom
Mario: MA CHE CAZZO
Mario: mangiando (eating)
Timmy: I fucked your mom
Mario: MA CHE CAZZO
by The comically random gamer June 04, 2023