Buttpuke Share definition Flag diarhea varying in substance, usually containing lumps, chunks, and hot slime which burns the cornhole. Resembling vomit expulsed rectally. I won't be in to work today, I have a case of buttpuke. Buttpuke by Steve January 6, 2003 0 0 Get merch Get the Buttpuke mug. Buy Now — $32.95 See more merch