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it is code for when you and a selected buddy, friend, frat brother, etc...want to have to have a threesome with an escort, slut, whore, etc...

also can be used to describe an threesome encounter that has already occured.
"checkout that little brunette with the tramp stamp and navel ring. let's see if we can pull off a You, Me, and Dupre!"

"last night was great. Eddie and I had a You, Me, and Dupre with Kathy! What a slut!"
by Mogiashi March 20, 2008
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