A question that means "hi" or "What are you doing"
It can get annoying, but people don't seem to understand that.
The best way to answer is "I think it's the opposite of down" if you are annoyed by this question

"What's up?"

what's up by The Billionth Random Monkey December 15, 2014

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What's Up?

1. A casual greeting or conversation starter, somewhat of a rhetorical question.
Usually followed by something like "Not much, you?," "Nothing much," or even answered with a "Hey man, how's it going?"
syn: How's it going? What is new?

2. syn. What can i do for you?, What would you like? What's on your mind?

1. Person #1: Hey There! What's up?
Person #2: Oh not much. What's up with you?

2. Person #1: Hey come here for a second, I have to ask you something.
Person #2: Ok, what's up?

What's Up? by GangstaRL December 28, 2005

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what's up

see also: whazzup, whassup, whasabi!!, etc.
1. Hi
2. Wtf is wrong with you??

It's probably originated from the late 20th century, when people were astounded with the sky. The only thing that they would reply was "nothing"

Probably the first term to the decline of western civilization

1. Person 1: What's up?
Person 2: "Nothing" (most common response, maybe 99% of people say that)

2. Person 1: What's up?
Person: "The sky" (smart alleck answer: also: "the ceiling" or, "da roof")

what's up by FunkdogdiggityJ-izzle mister blah?? i'm in the house yo, so holla at me after mah home fries get back! word! April 7, 2004

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what's up

Possibly derived from "what's the update." Extremely overused, almost exclusively by America's youth.
Sometimes I wonder why people always ask each other the same question over and over again, when answer is always "nothing." Are we really that dull?

Mike: What's up?
Matthew: Nothing. If you ask me again I'll roast you.

what's up by Renaissance Woman 4 u January 8, 2005

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