Vagimones are chemicals released by a gland in the body that send out messages that affect the organism's brain, rendering the organism completely useless and unable to stop bitching. Only a little amount of vagimone is required to alter the organism, and make the newly altered organism a complete pain in the ass.
Alex: "Where's Ryan?"
Mike: "He said our jokes were too mean, and went home."
Alex: "Sounds like his vagimones are acting up again."
When an average looking man picks up the most beautiful girl at the party, only to get her home and find that her penis is bigger than his.
Joe: Dude, did you see who Bill left with?
Dude: You mean that tranny Jill?
Joe:Jill is a tranny?
Dude: Yes, and Bill is in for a serious case of vagirony.
With her keen sense of vagirony, Sarah Silverman was able to tell a story about her nasty yellow discharge that made her endearing to an even larger number of horny men.