Transvesdyke Share definition Flag A guy who undergoes a transgender operation with the intention of dating lesbians. He didn't have much luck with the straight girls so now he is giving it a go with the lesbians as a transvesdyke. Transvesdyke by cougar smurf October 17, 2009 0 0 Get merch Get the Transvesdyke mug. Buy Now — $32.95 See more merch