The Seth Rogen 

1) When you're pretty high and you can't keep your gut in

2) feeling bloated after eating a dope ass snack

1) Dude I'm so high, im doin The Seth Rogen
2) I feel like Seth Rogen bro

The Seth Rogen by Smalltownassbutt May 4, 2019

The Seth Rogen Gene

A gene that when injected into your bloodstream gives you the appearance of being funny even though you've said nothing funny

You: So what's this one?
Doctor: The Seth Rogen gene, it gives you the appearance of being funny even though you've said nothing funny.
You: Oh... Hey doc are we done here? I gotta grab some beers with the fellas.
Doctor: HAHAHA! THAT IS HILARIOUS!

The Seth Rogen Gene by BigJ91 September 29, 2011

The seth Rogan effect 

The effect when a actor play's the same person in every movie.

The Seth Rogan effect means he play's basically the person in every movie he has appeared in.

The seth Rogan effect by Joe_mama_666999 April 19, 2022

Joseph James Rogan & Seth Aaron Rogan: The First Juvenile Release. 

What I call homo-sapien who are addicted to perianal abscesses.

Person 1: Are you addicted to perianal abscesses?
Person 2: Yes.
Person 1: Joseph James Rogan & Seth Aaron Rogan: The First Juvenile Release.

Joseph James Rogan & Seth Aaron Rogan: The First Juvenile Release. by LeSouffleDeVersailles February 8, 2025