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Stands for That’s Most Definitely What’s Up.

Variation of TWU- That’s What’s Up.

Common utterance of the lolcow species known as King Cobra JFS; an emphatic variation of That’s What’s Up, when something is *especially* bitchin’.
Cobes: This jalapeño, bacon and Hi-C Ecto Cooler mead that I made hardly has any botulism in it, TMDWU!
TMDWU by Trash K April 10, 2024
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That’s most definitely what’s up. Used by Wyomingites who are goth sexy bad boys to express strong agreement.
Ozzy Osbourne doing heroin. TMDWU!
tmdwu by Nick1288 April 19, 2024
Related Words
That’s most definitely what’s up or that is most definitely what is up. Popularized by the fan/trolls of YouTube icon, King Cobra JFS.
Mixing monster, bud light platinum, and Dorito dust? TMDWU
tmdwu by Hybridjap April 29, 2024
Acronym associated with KingCobraJFS in a YT music video titled as above. Means "That's Most Definitely What's Up."
"Night out with the boys, TMDWU"
tmdwu by saltifry August 21, 2024

tmdwiaww 

tmdwiaww is also the title of a song by evann mcintosh
Stands for “Too many definitions in urban dictionary”. Refers to the fact that many often unsettling concepts exist in the world and use of the Urban Dictionary can make one aware of them.
Today I learned the true meaning ofdirty sanchez” because tmdiud.
tmdiud by murphnomer March 6, 2022
well known from south park
rednecks get angrry that future folk took there jobs so they yell
They took ouare jerbs!
Them future folk took ouare jerbs!
jerb by Jimberley Kim April 7, 2005
Word of the Day on May 22, 2026