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refers to video games where an objective is present, and stands for Play The Fucking Objective.
Quit being a Bush Wookie and P.T.F.O.!
P.T.F.O by jdawghatesyou August 8, 2011
Have you seen Dancia recently?

Dude, she's on the couch PTFO.
Doesn't surprise me.
P.T.F.O by AaronPetray February 24, 2005

R.A.B.G.A.F.B.A.N.B.B.B.H.F.S.F.S.O.M.A.Y.H.C.T.P.T.F.O.A.S.A.R.A.N 

Idk lol
"Your such a R.A.B.G.A.F.B.A.N.B.B.B.H.F.S.F.S.O.M.A.Y.H.C.T.P.T.F.O.A.S.A.R.A.N"
"Penis"
"I'm leaving. ptfo!"
P.T.F.O by mjg July 28, 2005
Pissed the fuck off
"dude, when I lost my wallet I was P.T.F.O.
P.T.F.O by Radarhut March 3, 2011

P.T.F.O. 

yo homie im fuckin smashed iv P.T.F.O., goodnight
P.T.F.O. by mrmagic172 December 6, 2011