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refers to video games where an objective is present, and stands for Play The Fucking Objective.
Quit being a Bush Wookie and P.T.F.O.!
P.T.F.O by jdawghatesyou August 8, 2011
Acronym for "Passed The Fuck Out" inspired by university acrynyms.
Have you seen Dancia recently?

Dude, she's on the couch PTFO.
Doesn't surprise me.
P.T.F.O by AaronPetray February 24, 2005

R.A.B.G.A.F.B.A.N.B.B.B.H.F.S.F.S.O.M.A.Y.H.C.T.P.T.F.O.A.S.A.R.A.N 

"Your such a R.A.B.G.A.F.B.A.N.B.B.B.H.F.S.F.S.O.M.A.Y.H.C.T.P.T.F.O.A.S.A.R.A.N"
"Penis"
P.T.F.O by mjg July 28, 2005

P.T.F.O. 

yo homie im fuckin smashed iv P.T.F.O., goodnight
P.T.F.O. by mrmagic172 December 6, 2011