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When a person has so much, and such extreme acne, that it looks like they have an STD similar to Syphilis.
I scored with Amy last night, but I had to skip first base because of her Syphizits.

No girl is every going to want to kiss me, have you seen my Syphizits?
Syphizits by iRod December 27, 2012
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The most hottest sexiest guy you'll ever meet. This guy has a enormous dick and an even bigger anime thigh fetishes. He will 360 no-scope anyone and doesn't give 2 fucks about what anyone has to say about him.
God damn Syphixn's dick is so big. And the way he 360 no-scoped that guy was seggsy.
Syphixn by syphixn March 27, 2021