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To make something shit. To break it, or to totally ruin it.
"If you keep doing that dude, you're going to Stuxify it..."

"Oh great, it looks like this thread has been Stuxified..."

"WARNING.... Stuxification imminent..."
Stuxify by Wizard Of Odd September 16, 2008
Related Words
To take something very difficult to understand and dumb it down so anyone can understand it.
While speaking with my customer about their network services, I had to stupify much of our conversation so they would understand me.
Stupify by NOCManager April 23, 2009

Stupifyin Jones 

This is based on the widly overdrawn creative and overtly sexual comic strip of Al Capp.And it would be when you complete destroy your budget and look so fabulous that everyone is stupified into being wordless and motionless.In the broadway musical Lil Abner based on Dogpatch USA, Stupifyin Jones was played by Julie Newmar (tv'sCatwoman)
I am not eating for 2 weeks but when i went to the new restaurant in this amazing Versace i definitely inflicted some cosmically fatal Stupifyin Jones.
Stupifyin Jones by DaynaS March 28, 2008
One of the best songs of the world from disturbed.
Look in my face, stare in my soul
I begin to stupify. Ah! x4
Look in my face, step in my soul x4
Look in my face! x3
I begin to stupify! Ah!
stupify by Deathtoll October 19, 2005
it can have many meanings, the one i know of is
to stupify is to
grab somone and smash their head on a rock in an attempt to either kill them or cuase brain damage to make them stupid.
its a verb in the definition

i will stupify you(threat)
stupify by Trevor April 1, 2004
To confuse someone by the use of sheer stupidity. President Bush does it to you Americans often just no one seems to notice
Guy 1: Hey man ever eaten your breakfast out of a toilet bowl ?

Guy 2: What ?

Guy 1: How about walked into a womans wide vagina ?

Guy 2: Huh?

Guy 1: Yeh ! Stupify-ed you good !

Guy 2: Oh yeh nice one
Stupify by PerthBoy December 9, 2008