Top definition
When an individual from UMass-Amherst male/female is only attracted to Southwest dudes and bettys.
John:I use to live in Lewis in Northeast, but now I live in Patterson in Southwest and have been diagnosed with this syndrome.

Jake: What syndrome?

John: SOUTHWEST SYNDROME
by Fabio Rodriguez March 08, 2009
Get the mug
Get a Southwest Syndrome mug for your dad Jerry.