Ruppeled Share definition Flag To screw one's self over, or cause great harm to one's self. (Can be a physical act) Sally totally ruppeled her chances with bobby last night after accusing him of hooking up with his gay roommate. Ruppeled by kmbizzle April 6, 2008 0 0 Get merch Get the Ruppeled mug. Buy Now — $32.95 See more merch