Ruff Muff Share definition Flag Someone who has a dirty, smelly, rancid big hairy vagina. That Kelly sure has one hell of a ruff muff, don't have sex with her, you'll be sure to catch something. Ruff Muff by F meister May 18, 2006 0 0 Get merch Get the Ruff Muff mug. Buy Now — $32.95 See more merch