When someone takes too much (or a mix) of any supplement(s) for any purpose (although it relates predominantly to supplements of the 'work-out' variety) and their body reacts in a very violent and severe way usually involving the excess supplements being expelled from both the mouth and the anus. NB Supplement Pop is usually preceded by a moment of total clarity.
Gym Junkie #1: Damn man, I had soooo much of that Mega Whey I got massive Supplement-Pop!
Gym Junkie#2: Damn Brah, that sucks! Did it come out your ass and your mouth?
Ruler of Lake Titicaca. Rumored to have a bunghole that gets very angry if it does not receive toilet paper. Cornholio the Great is often seen walking around with his shirt over his head and his hands in the air, chanting songs about his power, and his bunghole.
"I am Cornholio! You do not want to face the wrath of my bunghole, for I need TP!"
Butthead: Shut up, Beavis! (uh huh huh huh)
Beavis: Um, okay. (heh heh heh heh).