This is a phrase commonly used throughout the UK to indicate to a friend, colleague or even a total stranger that they have seriously annoyed a number of other people by word, action or attitude and that they can expect repercussions.
"Malcolm's just changed a whole load of databases that took months to set up, system support are fuming, he's really pissed them off!"
by AKACroatalin March 29, 2015
Get the Pissed them offmug.