Piss and Moan Syndrome Share definition Flag Piss and Moan Syndrome (or PMS) is the male response to womens hormonal changes and bullshit "He's a big whiner...he might even have PMS...piss and moan syndrome" Piss and Moan Syndrome by linenmaster August 20, 2012 0 0 Get merch Get the Piss and Moan Syndrome mug. Buy Now — $32.95 See more merch