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perma fucked 

The state of being that resulted from long periods of drinking excessively.
LB tried to answer the cop's question but he was so perma fucked he couldn't even understand him.
perma fucked by d bo April 22, 2004

Perma Fucked 

(aka Chloe Ritter) when your brain has

Deteriorated Too the point of no return from the excessive use of methamphetamines. Akaa The boofaaLoompa of Bristol
That tweaker is perma fucked !

Permafucked 

Being permanently Fucked.
"Yea, I've just been permafucked... my car's gone..."
Permafucked by Eric Zabowski February 2, 2009