The state of being permanently altering your future or your body negatively, due to injury or a retarded decision.
I cut the nerves and tendons in my finger and now it's perma-fucked. I knocked a random girl up after a one night stand and now I'm Perma-fucked
by Bonnie's hubby May 04, 2017
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The state of being that resulted from long periods of drinking excessively.
LB tried to answer the cop's question but he was so perma fucked he couldn't even understand him.
by d bo April 22, 2004
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