To have done so many drugs, that one would expect you to be affected by drugs 24/7, even though you might not be, but you probably are.
James: Alex are you high?
Alex: Dude i dont even know i have done it like four times today already.
James: you must be perma-fried
Alex: Dude i dont even know i have done it like four times today already.
James: you must be perma-fried
by Free Weezy June 08, 2010
by minghi May 22, 2003
by MF September 06, 2002
which the user of the drug (mainly LSD) feels some effects of the drug (example; sever memory loss) for a vary long time after use of the drug year possibly longer ( the conduction will get better over time but user may never feel quite the same)
by cody ( just did big @$$ report on lsd) May 29, 2003