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A less formal way of saying Okay. It is given as a cheerful, bright... less intimidating response. It is also more used online rather than irl.
someone says "I'll be right back"
You reply with "okies"

Someone is doing something that doesn't bother you, you reply with "okies"...

someone is annoying you and your pissed off you say "Okay".. not "okies"
okies by anon March 5, 2004
Related Words
another word for ok e.g. OKies,YOYOYOYO
Bill: you alrite
Ben: im gd
Bill: Okies
OKies by Checken April 15, 2008
an agreement, can be used like ok
or may be used as an acknowledgement
"meet you in town today" "okies"
"hey i saw you-know-who on the cam today" "okies"
Okies by daniel mcleod April 8, 2004

You okies? 

You okies is a cute way of asking how a person is doing. You would use okies for somebody whom you're forming a relationship with. It's a modification of the question "are you okay?"
Person 1: "Hey girl! You okies?"
Person 2: "I'm okies. How are you boy?"
Person 1: "I'm good I'm just kickin' it <3"
Person 2: "ily <3"
You okies? by _Blode September 17, 2018

Okiesmokie 

A really wordcool/word guy
damn, Okiesmokie is cool
Okiesmokie by Steven October 14, 2003
a completely inane and unintelligent way of responding to any and all statements and questions. It invalidates any form of sapient nature in the human being using it, and very possibly rips a hole in the space-time continuum that grows slightly larger every time this word is used.
sUpa C00ol D00d: I'm going outside now.

h0tt13 4 l1f3: okies!
__

sUpa C00ol D00d: I'm really gay lovers with your identical twin cousin Enrique Pablo Martinez. How does that make you feel?

h0tt13 4 l1f3: okies!

__

sUpa C00ol D00d: I'm missing my Backstreet Boys CD. Have you seen it?

h0tt13 4 l1f3: okies!
okies by E. Greye December 9, 2008