This is a term usually reserved for situations where the only solution for avoiding an untimely death is to run for the hills. While this term is sometimes seen in lower case, it is always screamed at the top of ones lungs, usually right before the person behind them is killed/maimed/turned into a newt.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.