Something that makes absolutely no sense in the context of a sentence, story, TV show, book, play or movie. Alternatively, something that is incredibly out of place.
This term originated from Cleolinda Jones' LiveJournal recaps of the television show Lost. In one of the early episodes, the characters come across a vicious polar bear in the middle of the jungle. This animal was so out of place and out of context that in her recap, Cleolinda referred to it as the "OMGWTFPOLARBEAR".
Person 1: What is a My Little Pony doing in the middle of an action shot in Transformers?
Person 2: OMGWTFPOLARBEAR!?
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.