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Kinda like “no shit” or “no kidding.”
Wayne Campbell from Waynes World coined this phrase.
Wayne and Garth walking through a desert.

Garth: “Wow we really are in the desert.”
Wayne: “Sha, no guff.”
no guff by thetartag March 27, 2020
Related Words

"no guff" 

means.... "no shit dick tracy... are you a loser not to know that"
one: madonna is a whore
two: yeah... "no guff".
"no guff" by oneleggedracer April 23, 2006

No guff, chet 

1. Interjection used to express disbelief at an understatement. Obviously; no shit.

2. Statement used to express general agreement with a friend. Fuckin' A'; for real; I heard that.

(Chet can be dropped in any usage)
1. Bill: Your leg is on fire!

Tim: No guff, Chet!

2. Carl: We really stepped in it this time.

Joe: No guff.
No guff, chet by squeezmunky February 16, 2010