Missy Poo Share definition Flag A cute person, usually a girl, who seems incapable of taking care of themselves. "I accidentally spilled juice on my shirt""Aww it's ok missy poo" Missy Poo by Talookatalika April 22, 2018 0 0 Get merch Get the Missy Poo mug. Buy Now — $32.95 See more merch