The psychological condition suffered by many fans of the comic strip 'The Middletons' when Beatrice Middleton is not seen in the strip. Symptoms of this include, but are not limited to: intense sadness, thoughts of 'Where is she?', and most importantly 'Why is she not here?'. This causes much depression. The only known cure is intense exercise or massages using Martian Mud, which is Beatrice Middleton's favorite massage cream.

Beatrice: What's wrong honey? You look sad. I know what it is, its Middleton's Disease, right?

Bryant: Yes, you haven't been in the strip for days. Where were you? I was beginning to think you'd never show.

Morris: Buddy, she can't be in every strip. She's got to have a break once in a while. She's your Gunny Granny, for crying out loud.

Midge: (laughing) You know, he's right. Just because she isn't in the strip doesn't mean she isn't here. (picks up a jar of Martian Mud) Do you want me to use this? You love it when Beatrice does it.

Bryant: A massage? You'd actually give me a Martian Mud massage? Okay, just make sure you go all over my body. That's the best one.

Beatrice: That's one way to cure it. Hey sweetie, there's a soccer game going on later. And I'm coaching it. Want to come?

Bryant: Sure, maybe we could bring Grandpa Hec and Grandma Flo. But would I still be sad if I came?

Beatrice: No, you wouldn't be sad. Middleton's Disease is tough, I know. But you'll get over it quickly. (she starts massaging Bryant with the Martian Mud) There you go, sweetie. Now, isn't that better? I love you, honey. And I always will. A Gunny Granny's gotta do what a Gunny Granny's gotta do.

Middleton's Disease by Dusty's Baby Powder June 18, 2011

Get merch

Middleterranean

A person that appears to be of Middle Eastern or Mediterranean decent, or a mix, and can also include north African ethnicities.

Katie: "I've been talking with this guy from Tinder, isn't he delicious?" (Shows photo)
Ashley: "Oh wow, he is hot! Where is he from?"
Katie: "I don't know, but I'm pretty sure he's Middleterranean. Just the way I like it!"

Middleterranean by E_Rocks October 26, 2015

Get merch

Middlesex School

Middlesex is one of the top boarding schools in the US. Founded in 1901 and located in Concord, MA, Middlesex has about 350 boarding and day students. In addition to a very rigorous curriculum, the school has a great arts program and strong sports teams, especially for a smaller school. Middlesex is a member of the ISL; its rival is St. George's. Graduates go on to some of the best colleges and universities. Middlesex has some pretty famous alumni, like Steve Carrell and Bill Richardson. The school has become much more geographically diverse in recent years, and the student body now comes from all over the country and the world. The kids are really preppy, but it's still a tight-knit community where everyone works hard and knows when to kick back and relax.

The Middlesex School boys lacrosse team has won the ISL championship 7 times in 10 years.

Middlesex School by pudgey006 August 12, 2010

Get merch

Middleton Spank

A spank given only and exclusively by Tyler Middleton. These spanks are priceless, sensational, as well as very precious to one’s arse. Getting one of these can cost a pretty penny, but is well worth the money.

Friend: “Why are you walking with a limp?”

You: “Just received a Middleton Spank.”

Middleton Spank by kurtcolayne October 22, 2019

Get merch

Shuffle