"Genetic Pokemon" with strong psychic powers. It was created by a scientist after years of horrific gene splicing and DNA engineering experiments.
Hooray! I just used my Master Ball and caught Mewtwo.
by Eyeballflyball July 08, 2003
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Probably the only Pokemon that's actually cool. The only Pokemon who seeks world domination and plots for him and his clones to inherit the world. He is the most powerful of all Pokemon and can withstand anything that comes his way.
Mewtwo: Behold my powers. I am the strongest Pokemon in the world!
by Woobie May 27, 2005
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Power manifested in a creature so vile, it makes you tremble to think how humans, through DNA splicing and engineering, were able to create such a monstrosity. Mewtwo is more than a pokemon, it's an example of the kind of power us humans would like to possess; that's why everyone connects with it and makes him the victor against any other creature. There's Deoxys, Lugia, Ho-oh, Groudon and Kyogre, there's Palkia, Dialga and even Darkrai but nothing really compares to the power and willingness to cause harm that Mewtwo possesses. It would be interesting though to face off Mewtwo against Arceus and witness Mewtwo obliterate Arceus from the inside out with the power of his mind done with but a single blink of his eyes!
Mewtwo concludes, "I wasn't born a Pokémon, I was created; and my creators have used and betrayed me! So, I stand alone!" Then goes on to destroy the entire facility along with everyone in it!
by Fiendermander January 09, 2008
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The sexual act of putting a pair of nail clippers in ones urethra and connecting an extension cord, and pulling it behind your back like a mewtwos tale. This process can take hours and be extremely painful. On the other side, you get a mewtwo tail and a dick extension. So the goods make the bads even.
"Whoa, dude! Did you get a Mewtwo?"
by Rubbar July 09, 2014
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The most awesome Pokemon ever. Originating from the cells of Mew, he was cloned, but when activated he quickly learneed his supposed purpose, grew angry, and destroyed the laboratory, killing many people. In essence, he is the only Pokemon cool enough to kill you, your friends, your family, and still be able to mix a refreshing drink out of your blood, and intestines.
Aw f***, it's Mewtwo! Everybody run!
by The Noid November 27, 2007
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1) The one Pokémon whom enjoys killing.
2) Coolest, Pokémon, EVER!
I just caught Mewtwo!
Mewtwo has a clone army!
by Crum May 22, 2004
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Just owns, pure owns

It is totally unstoppable, usually goes on killing sprees.
It tries to kill pikachu in a movie, but fails

It hides in a cave near Cerulean City and kills anyone who enters, unless you have a master ball.

The master ball is your only means of survival against this monster

Person 1: "Holy Shit man, i bumped into mewtwo yesterday"

Person 2: "How did u survive? Come you weren't killed like everyone else?"

Person 1: "I had a master ball!"
by Example555 January 30, 2009
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