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1. A tiny run down city or town, usually inhabited by many a mexican. Sometimes known as a "ghetto", but slightly different.

2. Isaac

(When referring to "Isaac" one may also use the shortened version "Barrs" or "Lil Barrio".

1. My grandma died in a Little Barrio.

2. Little Barrio died in my grandma.
by Little Barrio himself May 02, 2006
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