Something or someone who makes you weak, even if you are a very strong person

Whenever making a congratulatory remark, this is what you say. Made popular by Kamala Harris when she and Joe Biden won the presidency.

Related to the Superman movies: Superman's weakness.The only thing that can hurt the man of steel.

My definition:

A man/woman that calls someone their Kryptonite means that they are their weakness. Someone or something they have to stay away from because they want it even though it's not good for them or will hurt them.

Someone you want but can't have can be called your Kryptonite.

Strong ass Weed

Intellectually powerful enough and attractive enough to seduce the strongest willed Playas, Pimps, Macks,Daddies,Hubbies, and Champions.

Kryptonite is a compound consisting of the element krypton, according to chemical-forming "-ite" nomenclature of chemistry.
However, krypton is a planet where Superman Clark Kent comes from and the substance kryptonite from it due to the explosion is fatal to our Superman, i.e. the translucently green rocks you would see in the TV series and which make Clark Kent dizzy and feeble and can even kill him.
Thus figuratively, it means something that makes you weak, powerless and limp, i.e. your weakness, whenever it comes to you, because it can even weaken Superman, let alone you!

1.Tight mutha fuckin song by Purple All-Stars

2.Sum Strong Bud