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holy guacamole 

Nathan: *tells a story of utter perplexity*
Jeff: "Holy guacamole!"
avocado that happened to be strolling past: "nah man. im an atheist."

holy guacamole 

OH MY GAWD!!!
To be extremly shocked; in shock.
Tonia walked up to Bridget and said "I'm gonna have to repeat the grade!!"

"HOLY GUACAMOLE!!", Bridget exclaimed.

holy guacamole 

Person 1: Did you know stretch marks are permanent?
Person 2: holy guacamole!!
holy guacamole by Massiveturd December 20, 2009

holy guacamole 

A statement that can be loosely translated into "holy shit" or "holy cow" or anything that expresses extreme surprise.

Holy Guacamole is actually a restaurant in Santa Monica.
Wholly Guacamole is a brand of guacamole and other dips.
Jack: Hey Jill, lets go up the hill to fetch a pail of water!
Jill: OKAY!
(both go up the hill)
Jill: (trips)
Jack: HOLY GUACAMOLE! (trips)
holy guacamole by Omgeezus January 5, 2012

Holy Guacamole 

A less profane way of saying holy crap; a phrase to express astonishment.

A song by MF Doom featuring Paul Barmen.
Holy Guacamole, i think i wet myself!

Man, MF Doom and Paul Barmen need to make another song together, Holy Guacamole was awesome.
Holy Guacamole by -LSD- August 22, 2010

holy guacamole 

Used as a replacement to "holy moly" or "holy crap"
Chad told alex "holy guacamole", you are effing gorgeous!
Alex said "holy what? you mean holy moly?"
Chad then said "Guacamole>moly, get with the program."
holy guacamole by chad900 August 28, 2013