The experience of negative symptoms due to withdrawl from medication, typically opiates (herion, morphine, opium.) Symptoms may include nausea, headache, insomnia and restlessness. The term is not limited to opiate narcotics.
Being dopesick, the only time I've slept in the past few days, is when my body reaches the point of physical exhaustion. Weee!
Dome-sack v. The process, usually in gaming, of getting a headshot on someone and places your testicals on their face. This phrase has made its way into everyday slang to also mean to completely dominate/embarrass to an audience.
"Dude I just domesacked that dude halfway across the map with my M416!" or "I just domesacked you on that physicsproblem"
The experience of negative symptoms due to withdrawal from heroin.
These same symptoms are often experienced during withdrawal from other opioids, but someone possessing no experience with heroin ought not use the word to describe their own condition.
Big fat dope sack is a sack ful of marijuana or some people who take drugs call it heroin. Big fat dope sack is metioned in Dr.Dre's classic song 'Deep Cover'