Bust a rail Share definition Flag To sniff a line of cocaine, extacy, oxycontin or any powder drug. "Ey, whats good man? You wanna bust a rail?""Nah, I don't fuck with that shit." Bust a rail by VicBC February 22, 2012 0 0 Get merch Get the Bust a rail mug. Buy Now — $32.95 See more merch