When driving on a road with two or more lanes going in one direction, and vehicles occupy all lanes. Said vehicles drive at the same speed and evenly, barring other vehicles from passing. This event native to Denver, where many "undocumented workers" usually from Mexico attempt to drive without a valid driver's license or automotive insurance. These illegal immigrants therefore drive significantly under the speed limit, effectively infuriating all other drivers on the road.
Sorry I'm late for work today Mr. Jenkins. There was a Mexican road block on Interstate 25.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.