ay dios mio 

oh my god. ( in spanish ) mostly said when..
1. some one it's getting on your nerves.
2. some thing bad just happend.

1. Ay dios mio! Tu me tienes loca. Deja me ya.

2. Ay dios mio. I can't beleive you broke that. Mami is going to beat your ass.

ay dios mio by shy January 4, 2005

ay dios mio 

Oh My God in Spanish

Ay Dios Mio, tengo mucho tarea
Oh my God, I have so much homework

ay dios mio by Diane December 10, 2004

ay dios mio 

Often comically used for emphasis after a lame joke, similar to a groan.

Person A: "Did you hear about the fish that went deaf? He had to buy a herring-aid."
Person B: "Ay dios mio."

ay dios mio by subhuman85 August 16, 2006

Ay Dios Mio Coño 

A phrase that Domingo Ayala yells out whenever he feels pain or after he’s taken a swing during BP

(Domingo falls off bike) “Ay dios mio coño”

Ay Dios Mio Coño by Jahamez May 15, 2019