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To completely cut off or end an intimate relationship with a guy or girl.
Jeff: "Man, I caught her cheating again tonight. I know she loves me, but still it hurts every time. I don't know what to do."
Jeff's friend: "You know Jeff, I'm sorry about this, but I think we're going to have to amputate. Lock the doors, Marty!"
*Marty locks doors*
Jeff's friend: "You're not seeing her tonight, Jeff, or ever again."
by ebarb44 March 06, 2010
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timmy: hey mommy whens the next time i can visit my 5 year old sister? her black hole is cool.
mom: YOU SCREWED YOUR SISTER! then its time for some sexa amputation.

mom: woo i got a new dildo, i liked my dads better though.
by YO MY HO February 27, 2003
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