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to squint at someone when they have done something wrong or if they are going to do something wrong
Fred: i ate the last piece of cake...

Samuel: =.=
=.= by kdlfn October 7, 2010
An annoyed face often used in chat. Similar to -_- but a little more annoyed. More of a squint, or glare.
Person 1: lol you suck!
Person 2: .... =_= shut up
=_= by BaldDumboRat September 9, 2008
1. ‘is\are\am not equal to’

or

2. ‘is\are\am not the same as’



(See also: <, >, =, ^)
1. Kirbymak239 =/= Kirbymac293

2. the '=/=' denotation, used primarily by GF'rs, =/= the mathmatical sign '&#8800;' which is a non-ASCII-appropiate character and hence why it is not displayed here
=/= by Victor Van Styn August 23, 2005
A smiley derived from anime. Use to define exhaustion, or age.
Uhh... I'm tired. =_=
=_= by KamikazeH2OMelon September 25, 2005
Not equal to.
=/= by dj gs68 July 23, 2003
An expression used during a chat etc, to express that you are tired...
A - "Man this weekend sure will be fun!!"
B - "Lucky for you...I have heaps of work to do...=.="
=.= by Sukari March 19, 2004