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Tweak

a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme intoxication. Users were left alone when they "tweak," or are "tweaking out" until the initial strong effects of the drug wore off a little and they were more coherent.

The term has come to loosely refer to being high on speed, as well as unfortunately children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.
You might act a little crazy when you tweak, but you'll come down in a minute or two.
by Lady Artemis April 3, 2010
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Tweaker

A word used popularly in Philadelphia, Pa to describe female dogs who get “smutted” around by a group of men. The men are either friends, cousins or even siblings maybe complete strangers but that's rare with Tweaks. Tweakers are often exposed on the Tweaker List page via Facebook. Tweakers are not aware that they’re tweakers, until they appear on the Tweaker List. However, 99.9% are still in denial after being featured on every list. You can always find a Tweaker on Broad & Olney, King of Prussia, and Franklin Mills. They're in there like swimwear.
Girl: I'm not a tweak, I'm 15 years old and I let 5 guys hit.
I only sucked 14 dicks this year. Yes, I'm on the tweaker page, but these girls just hating on me because I had sexual intercourse with their boyfriends.

Boy: Your the true definition of a tweaker.
by Never Lying October 13, 2010
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Related Words

tweeker

Someone that you date for only two weeks
Aaron: are you still dating sarah?
Matt: no, she was a tweeker.
by banana rammer April 27, 2011
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tweaker

a person who has lost life. they say it can kill you the first time you try it...if it doesn't you will wish it had.
The most prettiest girl in school got caught up in tweak...she isnt so pretty now and she is really mean with big gashes in her face from picking at it and no eye brows cuz she must have got really bored and tweaked by herself...poor girl she will never be the same
by I dont care how they do it February 24, 2005
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tweaked

twisted generally related to events perceived while on hallucinogenic drugs, usually referring to an individual.
"Man, last night I dropped five microdots and ran up primrose hill naked! Boy was I tweaked!"

"I was out for a stroll on primrose hill last night and I saw a naked guy running around. He looked HIGHLY tweaked!"
by Simon November 9, 2004
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tweak

1. a person who is tweakin out from crack
2. a crack baby
by Krysti Moaner April 11, 2003
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tweakend

the act of tweaking out on the weekend. A tweakend starts saturday night around 10 pm and ends sunday night around that time.
pick up a dub sack or a 30-sack, find a spot, party up with a couple of fat lines now and another couple of fat lines around 3 am save some to share with another. party on by going to a club, or a walkabout all night.
i be smoking a gang of kush at the skatepark on saturday that i get so much euphoria that i end up pulling a tweakend saturday night after the park closes.
by skaterjack October 5, 2006
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