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your sister 

The person all your guy friends want to fuck when they realize she isn't just yur little sister any more- she's your little virgin sister who is hot now that she has boobs and shaves her legs.
"Damn! Your sister is hot! When did that happen!?!?"
"Dude as your best friend, would it be weird if I fucked your sister?"
your sister by Sexy Stephy June 6, 2004

Your Sister is a Mister 

The ultimate comeback that were Steven Hawking’s final blessings to us before his passing.
Steven: Your sister is a mister... *final breath*

Man: What an OG that man was

brain sister

An attractive twenty-something year old who is constantly occupied with a Texas Instruments calculator.
"She was a brain sister - texas instruments all day"
-"Brain Sister" by Limozeen

Hey Soul Sister!

1. A once-upon-a-time top song on iTunes
2. An upbeat tune from Train, who we practically thought was on the way down before they ripped this on off
Hey Soul Sister!... ain't that mister mister on the radio.
Hey Soul Sister! by CaintchuC April 23, 2010

Weak Sister 

1. A weak or undependable member of a group. 2. A person regarded as timid or indecisive.
Jim's a fuckin' weak sister, he couldn't decide whether to shit or go blind.
Weak Sister by zboss July 5, 2007

stove piped your sister 

To have meaningful sex with ones sister.
i.e. Hey ziggy, I stove piped your sister last night and she loved it.

nightmare sister colleague 

A workplace cohort who has taken it upon herself to take on the role of a nightmare sister, finding ways to endlessly embarrass, harass, prank and annoy you to the point of near-insanity.
When I wake up some mornings I find myself breaking out in a cold sweat just imagining the weird and unexpected things my nightmare sister colleague might do to me that day.