downsyndrome

Genetic condition caused by a triple chromosome also known as chromosome 21. People with this condition are blessed with the gift of eternal innocence. They are usually harmless and friendly and incapable of violence. We like to think they need help but maybe it's really us who do.

"George Bush is a perfectly sain individual, no history of downsyndrom there, he can wage war all he wants"

by Flo January 29, 2004

downside of advantage

having a disadvantage in a situation.

I applied for a job with the ACLU, but having a conscience and a brain put me on the downside of advantage.

by kimmie s November 12, 2006

downsin

A Greek term meaning 'cool', 'amazing', or the like.

You know Amy? She's 100% downsin.

by worddefiner461 January 4, 2009

Facebook Downsizing

Used as an alternate for defriending people off of Facebook.

action verb: The act of defriending a large group of people from one's Facebook because of a number of reasons (i.e. removing an ex, people you don't talk to any more, that random from the party last night, etc).

verb: to downsize one's Facebook friends

Tom: I decided to Facebook downsize after each school year.

Jerry: Yeah, I did some Facebook downsizing after I broke up with that whore Stacy. I didn't need her sorority Facebook stalking me anymore.

by Lord_Squeaks March 5, 2012

debbie downsie

a rachet, roadhard slut, crazy as all get out, with bat shit Asian gangham style bangs, who looks like she has a touch of the downs.

Shanon was looking rather Debbie Downsie last night, but I fucked her anyway.

by hokat November 14, 2013

Downsyde

the maddest ozzie hip hop band on the planet who are like much worshipped BRYZBAYNE

downsydes el questro rocks

by Anonymous April 14, 2003

Downside up

When an individual is the opposite of being upside down. Standing on his/her/it's head, downside up.

"Sebastian's mom was downside up on the table last night"

by Clumped March 18, 2017