downsie 

A playful, almost gentle way to refer to a person with Down's Syndrome. It can also refer to someone who acts as though they have Down's Syndrome.

Can be used as an adjective or a noun.

Ex: I wish I was a downsie. Then I could be put in a "special" home and be taken care of for the rest of my days. Responsibility is so overrated.

Ex: You are soooo downsie! I can't believe you forgot how to ride a bicycle!

downsie by chrismarcar March 11, 2007

Downsie 

To be a downer
To always be getting people down

Why you gotta be so downsie all the time......... BITCH

Downsie by QUIEZ January 9, 2009

debbie downsie

a rachet, roadhard slut, crazy as all get out, with bat shit Asian gangham style bangs, who looks like she has a touch of the downs.

Shanon was looking rather Debbie Downsie last night, but I fucked her anyway.

debbie downsie by hokat November 14, 2013

Gord Downie 

The most insane, hyper, and awesome musician of all times
Lead singer for the Tragically Hip

Cousin: hey stop using your gord downie voice with me

Gord Downie by el torped0 July 7, 2008

downside of street cred 

selling your soul to try to please some imagined audience

he bought the shoes and shirt but wasn't accepted so he found out about the downside of street cred.
Diluted standards and lowest common denominators are the dirty open secret of the downside of street cred.

downside of street cred by adam_before_eve September 24, 2005

Chocolate Fudge Downie 

A black person suffering from Down Syndrome.

That guy's a straight up Chocolate Fudge Downie

Chocolate Fudge Downie by hobofusion January 23, 2011

downset

opposite of upset

if your girl is ever upset, just tell her to downset

“told that upset b*tch to downset”

downset by winkdink November 12, 2019