by SSgt J's Wife January 20, 2005
Wise Mule Syndrome: A condition in which one cannot stop being a smart ass, regardless of race, culture, situation, alcoholic content, or media. While the contemporary social view is that clinical sufferers of this condition are choosing to be a smart ass, it is in fact, medically impossible for them not to be without the proper medication. If you encounter someone who has been diagnosed with WMS the proper response is to either back away slowly, or laugh at everything they say as the are inwardly sensitive and self-conscious. And awesome.
"I apologize for equating your bust to water balloons during my speech at your wedding reception last night. I suffer from WMS."
by iolympian February 16, 2014
by jarheadfor4 March 25, 2005
by salakommander December 10, 2006
by blankman 1 August 21, 2008
by Randomuser6352 May 05, 2020
by old school cool August 28, 2016