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Four eyes 

A well-known insult in the Japanese manga and anime world, used on people who wear glasses. The meaning 'Four-eyes' probably came from the two physical eyes the person has, while two more eyes seen on the glasses (one eye on each glass), which makes 'four eyes' in total.
Person 1: Oi, four eyes! Get me melon bread!
Person 2: I-I didn't get my allowance today...
Person 1: *kicks Person 2 in the gut* Hah?! Who do you think you are?
Person 2: *screams in agony * F-four eyes!!
Person 3: *smashes Person 1 with an uppercut*
Person 1: *K.O*
Person 3: Hey Person 2, you alright?
Person 2: *snot and waterworks flowing* T-thank y-you so much, Person 3! Thank you!
Four eyes by austinhornhead12 January 6, 2021

Four ckenins 

Four chickens spelt by a dyslexic person.
Person A: What the heck is four ckenins?
Person B: Four chickens but spelt by a dyslexic person.
Person A: why is it hot.

Person B: wtf
Four ckenins by Four_Spaces April 3, 2021
why the hell did you need to search up the word "four"
man im bored imma just search up the word "four" on urban dictionary
Four by notzinmor April 19, 2021
Tim Duncan is the best player to play The Four
The Four by SCTEX123 April 23, 2021

Four loko 

A fairly strong drink crafted by Ohio State University alumni that originally contained caffeine. Modern iterations are just 11% malt beer, flavor, and an absurd amount of sugar. Commonly consumed by underage students to get as drunk as possible for as cheap as possible.

Only the strongest can survive shotgunning a four loko
“Oh god, the four loko is hitting. I’m going to blackout tonight for sure.”

“The best frats sneak four lokos in for the girls and brothers!”
Four loko by Nepenthe12042 May 12, 2021

The Four Remorsemen 

The four incurable sexually transmitted diseases (Hep B, Herpes, HIV, and HPV) that instantly makes a person regret having unprotected sex upon diagnosis and represents a sexual plague for all humankind who want to screw condom - free.
The affect of COVID-19 will pale in comparison to that of the havoc created by The Four Remorsemen.