dope house Share definition Flag A house where dope heads (heroin addicts) live and "do there business" (shoot up and nod out). Friend: Look at all those dope heads going into that house.Me: it is a dope house... dope house by throwaway142000420 July 7, 2014 0 0 Get merch Get the dope house mug. Buy Now — $32.95 See more merch