A word used to describe any situation that is indescribably fucked up. When used out of these dire situations, it is acceptable for the surrounding people to laugh and throw excrement. Whether "shit-screwed" is appropriate in a give situation is completely up to the present audience, and thusly should be used with caution.
Thing 1: Dick Cheney just loaded up my face with bird shot!
Thing 2: Ahhh, thats sucks dude. You got royally shit-screwed.
Thing 1: Don't I know it. That criminal fucking raped everything above my penis with his 12-guage.
To really mess up big time, to fuck up with massively significant consequences.
On futurama, when Fry, pulled one of the lanterns from the old church, ruining Paul Revere's midnight ride; Professor Farnsworth informed him of his screwup of historical proportions by saying: "Fry, you dope! You've really screwed the granny this time.".
"Fry, you dope! You've really screwed the granny this time."
"You read from the Necronomicon and unleash Lord Cthulhu on Australia?! Well, it looks like you've really screwed the granny on this one."
What you say to your cellmates in central booking when they explain to you why they don't belong there. I recommend you rehearse these words because they can keep you from getting your ass kicked if you ever get arrested.
Really scary woman: He was the one pulling on my hair but the only reason they arrested me was 'cause he looked worse than me after I busted him in the head with that fire hydrant.